Table 3.

Association of tight glucose control vs usual care with outcomes among critically ill adults, stratified by tight control glucose goal

Subgroup of trialsa	Number of trials	Event number/total number (%)		OR (95% CI)	I2 (%)
		Tight control	Usual control
Mortality
Very tight control	2	12/392 (3.1)	19/369 (5.1)	1.11 (0.12–10.60)	73
Moderately tight control	4	98/1582 (6.2)	94/1651 (5.7)	1.10 (0.81–1.49)	0
Overall	6	110/1974 (2.9)	113/2047 (5.5)	0.95 (0.62–1.45)	40
Any hypoglycemia (< 60 mg/dl)
Very tight control	2	112/392 (28.6)	17/396 (4.3)	9.35 (1.49–58.83)	88
Moderately tight control	3	259/1533 (16.9)	99/1514 (6.5)	3.00 (2.07–4.34)	54
Overall	5	371/1925 (19.3)	116/1910 (6.1)	4.39 (2.39–8.06)	83
Severe hypoglycemia (< 40 mg/dl)
Very tight control	2	24/392 (6.1)	5/396 (8.7)	5.23 (1.95–14.00)	0
Moderately tight control	3	85/1533 (5.5)	22/1514 (1.5)	3.88 (2.41–6.26)	0
Overall	5	109/1925 (18.4)	27/1910 (5.8)	4.11 (2.67–6.32)	0
Sepsis
Very tight control	2	121/392 (30.9)	143/396 (36.1)	1.01 (0.43–2.41)	73
Moderately tight control	4	95/1582 (6.0)	132/1651 (8.0)	0.81 (0.59–1.12)	18
Overall	6	216/1947 (11.1)	275/2047 (13.4)	0.83 (0.63–1.08)	32
Dialysis
Very tight control	1	2/349 (0.6)	6/351 (1.7)	0.33 (0.07–1.65)	NA
Moderately tight control	2	67/1184 (5.7)	97/1165 (8.3)	0.64 (0.46–0.89)	0
Overall	3	69/1533 (4.5)	103/1516 (6.8)	0.63 (0.45–0.86)	0
Seizures
Very tight control	0	NA	NA	NA	NA
Moderately tight control	3	31/1533 (2.0)	31/1514 (2.0)	0.98 (0.59–1.63)	51
Overall	3	31/1533 (2.0)	31/1514 (2.0)	0.98 (0.59–1.63)	51

OR odds ratio, CI confidence interval, NA not applicable

^aVery tight control, glucose goal < 110 mg/dl; moderately tight control, glucose goal 110–140 mg/dl