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. 2018 Feb 27;9:367. doi: 10.3389/fimmu.2018.00367

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Copyright © 2018 Krijgsman, Hokland and Kuppen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of the different functional human NKT cell subsets. CD1d-restricted human NKT cells can be divided into subsets based on their TCR repertoire and cytokine profile. Type I NKT cells express the invariant Vα24Jα18 TCR α-chain and can be subdivided into five distinct functional subsets (indicated in green). In addition, type II NKT cells express a diverse TCR repertoire and can be subdivided into two functional subsets (indicated in blue). Upon activation, NKT cells secrete a unique pattern of cytokines, indicated for each subtype. Type I and type II NKT cells are able to switch between different functional subsets upon interactions within the TME. Abbreviations: NKT, natural killer T; TCR, T cell receptor; T_H, helper T; T_reg, regulatory T; T_FH, follicular helper T; TME, tumor microenvironment.