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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Brain Res Bull. 2017 Nov 11;137:53–70. doi: 10.1016/j.brainresbull.2017.11.007

Figure 3.

Figure 3

a, Quantitative immunoblots show the expression of TLR4 in brain tissue lysate. The intensity of TLR4 was normalized by the corresponding PSD-95 and GAPDH expression.

b, Bar chart illustrating an increase in normalized neural TLR4 expression for WT/SCZ mice (p<0.05) when compared with the control (WT).

c, Immunoblot show normalized expression of NF-κB in the brain tissue lysate of control (WT) and WT/SCZ mice.

d, Bar chart demonstrating upregulated (normalized) NF-κB expression for WT/SCZ mice when compared with the control (WT; p<0.05).

e, Confocal images (scale bar=20μm) illustrating an increased neural NF-κB expression (normalized fluorescence intensity) for WT/SCZ mice when compared with the control (WT; p<0.001)

f, Statistical comparison of NF-κB fluorescence intensity for WT/Control and WT/SCZ groups.

g, GFAP positive cell count increased per unit area (astrocyte/μm2) in the cortex of WT/SCZ mice when compared with the control (p<0.01; scale bar=20μm).

h, Bar charts illustrating the comparative distribution of GFAP positive cells in the brain of control (WT) and WT/SCZ mice.