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TAF, TFV, and CMX157 concentrations in preclinical mouse samples post-colonic administration of drugs.
| Mouse | Time (Hour) | TFV [ng/mL] | TAF [ng/mL] |
|---|---|---|---|
| 1 | 0.25 | AQL | BQL |
| 2 | 0.25 | AQL | BQL |
| 3 | 0.25 | AQL | 0.0321 |
| 4 | 0.25 | AQL | 0.0313 |
| 5 | 0.25 | AQL | 0.0854 |
|
| |||
| 1 | 4 | 11.6 | BQL |
| 2 | 4 | 6.49 | BQL |
| 3 | 4 | 19.1 | BQL |
| 4 | 4 | 8.05 | BQL |
| 5 | 4 | 15.1 | BQL |
|
| |||
| Mouse | Time (Hour) | TFV [ng/mL] | CMX157 [ng/mL] |
|
| |||
| 1 | 4 | 1.02 | 3.63 |
| 2 | 4 | 0.533 | 1.33 |
| 3 | 4 | 0.745 | 0.381 |
| 4 | 4 | 0.373 | 0.707 |
| 5 | 4 | 0.640 | 1.71 |
TFV AQL: >250 ng/mL
TAF BLQ: <0.03 ng/mL
