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Role of adipose tissue fibrosis in ectopic lipid accumulation. To store excessive energy as triglyceride is a fundamental function of adipose tissue, which is tightly regulated by hormones, such as insulin, and the sympathetic nerve. In addition, recent evidence has suggested that chronic inflammation is involved in this process. Particularly, interstitial fibrosis limits adipose tissue expandability, which finally leads to increased ectopic lipid accumulation.
