Table 3.
Association between ICD status and a clinical, genetic, and clinical + genetic model.
| Clinical model |
Genetic model |
Clinical + genetic model |
||||
|---|---|---|---|---|---|---|
| Factor | OR (95% CI) | p-Valuea | OR (95% CI) | p-Valuea | OR (95% CI) | p-Valuea |
| (Intercept) | 0.6 | 0.756 | 0.1 | 0.099 | 1.1 | 0.948 |
| Age | 1.0 (0.9–1.0) | 0.434 | – | – | 1.0 (0.9–1.0) | 0.234 |
| DA use | 4.5 (1.5–13.5) | 0.006 | – | – | 7.4 (2.1–26.2) | 0.002 |
| DRD1 rs5326 | – | – | 2.9 (1.1–7.6) | 0.026 | 6.1 (1.9–19.6) | 0.003 |
| OPRK1 rs702764 | – | – | 0.3 (0.1–1.1) | 0.072 | 0.2 (0.1–0.9) | 0.040 |
| OPRM1 rs677830 | – | – | 0.5 (0.2–1.2) | 0.105 | 0.5 (0.2–1.3) | 0.153 |
| COMT rs4646318 | – | – | 0.3 (0.1–1.5) | 0.140 | 0.2 (0.1–1.5) | 0.117 |
OR, odds ratio; 95% CI, 95% confidence interval; DA, dopamine agonist; ICD, impulse control disorder.
aSingle factor association from stepwise logistic regression with ICD status as dependent variable.
Significant p-values are highlighted in bold.