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. 2018 Feb 28;9:161. doi: 10.3389/fphar.2018.00161

Table 2.

The summary of the histopathological results of rats repeatedly inhaled with the mixture of SM and propylene glycol (PG).

Groups histopathology Groups Control Vehicle Low Middle High
0 PG1% PG1%+SM1% PG1%+SM5% PG1%+SM20%
No. examined 4 4 4 4 4
Liver
     No specific lesion 1 (25.0) 1 (25.0) 1 (25.0) 2 (50.0) 0 (0.00)
          Cell infiltration, mononuclear cells, 3 (75.0) 3 (75.0) 3 (75.0) 2 (50.0) 4 (100)
               multifocal
          Grades; minimal 3 3 2 2 4
                    mild 0 0 1 0 0
Lung
     No specific lesion 3 (75.0) 2 (50.0) 3 (75.0) 3 (75.0) 3 (75.0)
     Vascular mineralization, focal 1 (25.0) 1 (25.0) 1 (25.0) 0 (0.00) 1 (25.0)
          Grades; minimal 1 1 1 0 1
Nasal cavity
     No specific lesion 4 (100) 4 (100) 4 (100) 3 (75.0) 0 (0.00)
     Metaplasia, squamous cells, Line I 0 (0.00) 0 (0.00) 0 (0.00) 1 (25.0) 4 (100)
          Grades; minimal 0 0 0 1 0
                    mild 0 0 0 0 4