Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Feb 28;9:360. doi: 10.3389/fmicb.2018.00360

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Bonfim-Melo, Ferreira and Mortara.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Involvement of Rho-family GTPases and their effector proteins in actin mediated EA host cell invasion. Our work showed the recruitment of Rho-family GTPases, N-WASP and WAVE2 after EA contact with the host cell. None of these proteins alone is required for F-actin polymerization, but Cdc42 cycling between active/inactive states and Rac1 activation are important for EA internalization. RhoA promotes actin polymerization in stress fibers but inhibits this process at EA invasion sites, which abolishes parasite entry and reveals the negative role of RhoA in this process. Dashed lines represent the possible joint participation of Rac1/WAVE2 and Cdc42/N-WASP and the possible negative regulation mechanisms of Cdc42 and RhoA over Rac1 activity.