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Metabolic profiling reveals changes in choline metabolism of DLBCL patients treated with panobinostat. (a) Treatment arms (left) and treatment schedule (right) of the phase 2 trial. Blood samples were collected prior and post panobinostat in both arms. (b) Volcano plot showing circulating metabolites that significantly changed their levels after panobinostat treatment. (c) Box plot of plasma betaine determined for each patient pre and post panobinostat treatment.
