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CUDC-907 effect relies on the induction of PI3K dependency through choline pathway activation. (a) Viability (center) and caspase-3/7 activity (right) of OCI-Ly1 cells after 24 h at the specified treatments (120 nM panobinostat or 10 μM of AZD8186, GDC-0941 or CUDC-907). (b) Viability (left) and caspase-3/7 activity (right) of OCI-Ly1 cells transfected with CHKA siRNA and treated for 24 h with 100 μM of CUDC-907. Data are represented as ± SEM.
