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(A) Levels of miR-34a in CRC cells were here found to be higher than in normal colon tissues (P<0.001). (B) miR-34a expression validation in HCT116 and SW480 after ectopic expression (P<0.001). (C, D) miR-34a administered in combination with 5-FU resulted in significantly lower viability in (C) HCT116 cells and (D) SW480 cells than in any other group (*P<0.05).
