Table 2.

Summary of the antitumor targets of ivermectin

Target	Effect	References
MDR protein	Inhibition	[39]
Chloride channel	Increase of activity	[44]
Akt/mTOR pathway	Inhibition	[47]
P2X7/P2X7 receptors	Activation	[50,51]
PAK1 protein	Inhibition	[9,54]
WNT-TCF pathway	Inhibition	[57,58]
SIN3 domain	Inhibition	[59]
NS3 DDX23 helicase	Inhibition	[64]
Nanog/Sox2/Oct4 genes	Downregulation	[67]