Table 3.

Antitumor effects of ivermectin in vitro

Tumor type	Cell lines	[µM]	Effects	Reference
Human leukemia	OCI-AML2	5,	Induces cell death through upregulation of ROS.	[44]
	HL60	10,
	U937	15,
	K61a	20
Prostate cancer	DU145
	PPC-1
Human glioblastoma	U87	1,	Induces growth inhibition, apoptosis and anti-angiogenesis.	[47]
	T98G	5,
		10
Ovarian cancer	TYK-nu	0.1,	Inhibition of cell proliferation.	[9]
	KOC7C	1,
	SKOV3	10,
	RMUG-S	100
	HEI-193
Breast cancer	MDA-MB-435,	5,	Stimulates autophagy and inhibition of cell proliferation.	[54]
	MDA-MB-231	10,
	MDA-MB-468	15,
	MDA-MB-361	20
	MCF-7
	HS578T
Murine breast cancer	4T1.2	1,	Induces apoptosis and necrosis. Induces autophagy.	[50]
	DDHer2	4,
		8,
Murine melanoma	C57BL/6	16	Inhibition of cell proliferation and clonogenic capacity.
Murine colon adenocarcinoma	CT.26		Increases the amount of ROS.
Human breast cancer	MDA-MB-231
	MCF7
	SKBR3
Human melanoma	A2058
	A375
Human pancreatic cancer	PANC1
	MiaPaca2
Human prostate cancer	DU145
Human head and neck cancer	A253
Human leukemia	MV411
Human colon cancer	CC14	0.1,	Inhibits cell proliferation and induces apoptosis.	[57]
	CC36	1,
	Ls174T	5,
	HT29	10
Human glioblastoma	DLD1
	U251
Human melanoma	SKMe12
Murine breast cancer	4T1	0.01,	Inhibition of invasiveness and restoration of tamoxifen sensitivity.	[59]
	MMTV-Myc	0.1,
Human breast cancer	MDA-MB-231	1	Inhibition of cell growth and metastases.
	D3H2LN
Human breast cancer	MDA-MB-231	0.2,	Preferentially inhibits cell viability and clonogenicity of the stem cell population.	[67]
		0.4,
		0.8,
		1,
		5,
		8