Table 4.

Antitumor effects of ivermectin in vivo

Tumor type	Tumor cell line	Days of treat.	Dose mg/kg	Mice	Effects of Ivermectin	Ref.
Murine leukemia	MDAY-D2	10	3,	NOD/SCID mice	Reduces tumor volume up to 70% in all models	[44]
			5,
			6
			i.p.
Human leukemia	K562		3 oral
	OCI-AML2
Human glioblastoma	U87	21	40	SCID mice	Reduces tumor volume up to 50%	[47]
	T98G		i.p.
Breast cancer	MDA-MB-231-GFP	10	2.4	NOD/SCID mice	Reduces tumor volume up to 60%	[54]
			i.p.
Human glioma	U87MG	42	3,	Balb/c nude mice	Reduces tumor volume up to 50% at 3 mg/kg.	[64]
			10		At 10 mg/kg tumors were not detectable
			i.t.
Human colon cancer	LDL1	21	10	NMRI nude mice	Reduces tumor volume up to 85% (LDL1 cell line). No effect is observed in the tumor TCF-independent cell line (CC14)	[57]
	CC14		i.p.
	HT29

i.t.: intratumoral. i.p.: intraperitoneal.