Table 2.
Parameters of mineral-bone metabolism and related variables in orthogeriatric patients by bone turnover status
| Variable | Bone turnover status | ||||||
|---|---|---|---|---|---|---|---|
| Subtype 1 | Subtype 2A | Subtypes 1+2A | Subtype 2B | Subtype 3 | Subtype 4A | Subtype 4B | |
| P1NP, µg/L |
46.20±18.71 | 22.85±5.85*** | 30.26±15.88 | 14.83±3.98*** | 23.02±5.84*** | 112.02±142.45*** | 50.45±19.57*** |
| bCTX, µg/L |
0.195±0.038 | 0.160±0.049*** | 0.171±0.048 | 0.190±0.036** | 0.458±0.210*** | 0.563±0.405*** | 0.740±0.317*** |
| P1NP/bCTX | 247.62±112.04 | 151.88±52.31*** | 182.28±88.34*** | 78.30±15.52*** | 57.17±22.82*** | 187.12±113.49 | 71.96±17.98*** |
| OC, pg/ml |
5.91±2.35 | 4.02±1.86*** | 4.62±2.21 | 3.86±2.65* | 4.60±2.30 | 8.48±5.32*** | 8.60±5.13*** |
| P1NP/OC | 9.36±6.58 | 6.82±3.51*** | 7.63±4.83 | 4.75±2.04*** | 6.15±3.30*** | 15.48± 17.21*** | 7.28±4.16 |
| PTH, pmol/L |
6.88±6.33 | 6.80±4.99 | 6.82±5.44 | 8.49±5.69* | 7.67± 5.21 | 6.30±4.52 | 8.65±6.09*** |
| 25(OH)D, mmol/L | 62.55±21.54 | 63.22±23.67 | 63.00±22.97 | 62.23±23.67 | 62.78±26.67 | 64.53±25.85 | 61.04±29.37 |
| Ca (corrected), mmol/L | 2.41±0.14 | 2.38±0.11 | 2.39±0.12 | 2.36±0.14 | 2.38±0.14 | 2.44±0.13*** | 2.41±0.14 |
| PO4, mmol/L |
0.87±0.22 | 0.83±0.24 | 0.84±0.23 | 0.77±0.24* | 0.84±0.23 | 0.98±0.23*** | 0.97±0.25*** |
| Mg, mmol/L |
0.79±0.08 | 0.77±0.09 | 0.78±0.09 | 0.77±0.10 | 0.76±0.11* | 0.76 ±0.10* | 0.76 ±0.09* |
| ALP, IU |
78.73±27.66 | 66.85±26.47* | 72.00±27.18 | 59.32±17.62*** | 73.48±38.20 | 112.28±104.33*** | 91.43±72.98*** |
| GGT, IU |
44.30±33.46 | 47.02±72.78 | 46.15±62.88 | 40.32±51.53 | 49.41±64.69 | 62.88±82.82* | 51.16±84.28 |
| Albumin, g/L |
34.49±3.87 | 33.90±4.06 | 34.09±4.00 | 32.82±3.6* | 31.03±3.85*** | 32.34±4.72*** | 31.07±4.40*** |
| TSAT, % |
12.52±7.68 | 11.51±7.63 | 11.82±7.64 | 9.68±6.38 | 9.65±7.00*** | 12.63±8.38 | 12.04±9.54 |
| Hb, g/L |
117.10±17.90 | 115.01±17.56 | 115.7±17.65 | 107.37±16.66** | 107.71±18.03*** | 109.00±16.93*** | 106.89±18.02*** |
| GFR, ml/min/1.73m2 |
79.43±10.50 | 78.47±14.11 | 78.77±13.05 | 74.96±14.75 | 74.24±16.77*** | 71.58±19.51*** | 67.39±22.45*** |
| Age, years |
74.4±8.63 | 75.5±8.66 | 75.1±8.65 | 77.6±8.60 | 80.4±9.17*** | 76.6±9.25 | 80.3.5±9.92*** |
Subtype 2A is compared with subtype1, while subtypes 2B, 3, 4A and 4B are compared with combined data for subtypes1 and 2A; *, p<0.05. **, p<0.01, ***, p<0.001.
Abbreviations: P1NP, N-terminal propeptide of type I procollagen; bCTX, C-terminal βcross-linked telopeptide of type I collagen; OC, osteocalcin; PO4, phosphate; Cac, calcium corrected for albumin; Mg, magnesium; ALP, alkaline phosphatase; GGT, gamma-glutamyltransferase; 25(OH)D, 25hydroxyvitamin D; PTH, parathyroid hormone; TSAT, transferrin saturation; Hb, haemoglobin; GFR, glomerular filtration rate.