Table 3.
Independent and significant clinical and biochemical correlates/predictors of bone turnover status in orthogeriatric patients
| Variables | Bone turnover status | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subtype 2B | Subtype 3 | Subtype 4A | Subtype 4B | |||||||||
| OR | 95%CI | P Value | OR | 95%CI | P Value | OR | 95%CI | P Value | OR | 95%CI | P Value | |
| Age | 1.06 | 1.03-1.08 | <0.001 | 1.05 | 1.03-1.07 | <0.001 | ||||||
| Age>75yrs* | 1.87 | 1.01-3.47 | 0.048 | 2.49 | 1.64-3.79 | <0.001 | 2.51 | 1.65-3.82 | <0.001 | |||
| Anaemia | 1.82 | 1.15-2.87 | 0.010 | 1.57 | 1.00-2.47 | 0.048 | ||||||
| CKD | 2.04 | 1.16-3.58 | 0.013 | 3.08 | 1.78-5.32 | <0.001 | ||||||
| CHF | 3.01 | 1.13-7.97 | 0.027 | |||||||||
| History of malignancy | 2.16 | 1.04-4.48 | 0.039 | 2.17 | 1.02-4.60 | 0.045 | ||||||
| Hyperparathyroidism | 1.87 | 1.01-3.46 | 0.046 | |||||||||
| Hypoalbuminaemia | 2.48 | 1.62-3.80 | <0.001 | 1.6 | 1.03-2.49 | 0.036 | 2.14 | 1.44-3.19 | <0.001 | |||
| OPT | 0.32 | 0.19-0.56 | <0.001 | 0.29 | 0.17-0.49 | <0.001 | 0.25 | 0.15-0.44 | <0.001 | |||
| Walking aids use | 2.3 | 1.32-3.12 | 0.001 | |||||||||
Only statistically significant associations (compared to subjects with subtypes 1 and 2A) are shown. The backward stepwise regression models included dementia, CHF, anaemia (<120g/L), CKD (GFR<60 ml/min/1.73m2), history of malignancy, diabetes mellitus, vitamin D insufficiency ( 25(OH) D<50 mmol/L) or deficiency ( 25(OH) D<25 mmol/L), hyperparathyroidism (PTH>6.8pmol/L), hypoalbuminaemia (<33g/L), use of walking aids, nursing home residence, alcohol use (> 3 times/week), smoking (current and previous), use of anti-osteoporotic medications (>3 months) and adjusted for age and gender. * evaluated in separate models.
Abbreviations: OR, odds ratio; CI, confidence interval; CKD, chronic kidney disease; CHF, chronic heart failure; OPT, osteoporotic therapy; GFR, estimated glomerular filtration rate.