Fig 1.

Analysis of gene expression in rectal cancers with preoperative concurrent chemoradiotherapy using a published transcriptome dataset (GSE35452). A clustering analysis of genes focused on cell motility (GO:0048870) revealed that SERPINB5 is the most significantly up-regulated gene in non-responders compared with responders. Tumors classified as responders (yellow) or non-responders (blue) are illustrated at the top of the heat map, and the up-regulation and down-regulation of gene expression are represented as a continuum of brightness of red or green, respectively. Tumors with an unchanged transcriptional level are in black.