Table 1.
Significantly deregulated genes associated with cell motility (GO:0048870) based on CCRT response in rectal cancer
| Probe | Comparison log2 ratio | Comparison P-value | Gene Symbol | Gene Name | Biological Process | Molecular Function |
|---|---|---|---|---|---|---|
| 204855_at | 1.3577 | <0.0001 | SERPINB5 | serpin peptidase inhibitor; clade B (ovalbumin); member 5 | cell motility | serine-type endopeptidase inhibitor activity |
| 205844_at | 1.2511 | 0.0002 | VNN1 | vanin 1 | cell motility, nitrogen compound metabolic process | GPI anchor binding, hydrolase activity, hydrolase activity; acting on carbon-nitrogen (but not peptide) bonds, hydrolase activity; acting on carbon-nitrogen (but not peptide) bonds; in linear amides |
| 209114_at | 0.9852 | 0.0002 | TSPAN1 | tetraspanin 1 | cell adhesion, cell motility, cell proliferation | |
| 202203_s_at | 0.9747 | 0.0001 | AMFR | autocrine motility factor receptor | ER-associated protein catabolic process, cell motility, signal transduction, ubiquitin cycle | ligase activity, metal ion binding, protein binding, receptor activity, ubiquitin-protein ligase activity, zinc ion binding |
| 220446_s_at | 0.7544 | 0.0004 | CHST4 | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 | N-acetylglucosamine metabolic process, carbohydrate metabolic process, cell adhesion, cell motility, cell-cell signaling, immune response, inflammatory response, protein amino acid sulfation, sulfur metabolic process | N-acetylglucosamine 6-O-sulfotransferase activity, sulfotransferase activity, transferase activity |
| 207080_s_at | 0.7389 | 0.0092 | PYY | peptide YY | G-protein coupled receptor protein signaling pathway, cell motility, cell proliferation, cell-cell signaling, cytoskeleton organization and biogenesis, digestion, feeding behavior | hormone activity |
| 1558549_s_at | 0.6644 | 0.0022 | VNN1 | vanin 1 | cell motility, nitrogen compound metabolic process | GPI anchor binding, hydrolase activity, hydrolase activity; acting on carbon-nitrogen (but not peptide) bonds, hydrolase activity; acting on carbon-nitrogen (but not peptide) bonds; in linear amides |
| 204035_at | 0.6374 | 0.0004 | SCG2 | secretogranin II (chromogranin C) | MAPKKK cascade, angiogenesis, cell motility, endothelial cell migration, eosinophil chemotaxis, induction of positive chemotaxis, inflammatory response, intracellular signaling cascade, negative regulation of apoptosis, negative regulation of endothelial cell proliferation, positive regulation of endothelial cell proliferation, protein secretion | calcium ion binding, chemoattractant activity, cytokine activity |
| 201012_at | 0.4402 | 0.0035 | ANXA1 | annexin A1 | anti-apoptosis, arachidonic acid secretion, cell cycle, cell motility, cell surface receptor linked signal transduction, inflammatory response, keratinocyte differentiation, lipid metabolic process, peptide cross-linking, regulation of cell proliferation, signal transduction | calcium ion binding, calcium-dependent phospholipid binding, phospholipase A2 inhibitor activity, phospholipase inhibitor activity, phospholipid binding, protein binding, protein binding; bridging, receptor binding, structural molecule activity |
| 1555551_at | 0.2908 | 0.0002 | SERPINB5 | serpin peptidase inhibitor; clade B (ovalbumin); member 5 | cell motility | serine-type endopeptidase inhibitor activity |
| 206941_x_at | 0.1285 | 0.0057 | SEMA3E | sema domain; immunoglobulin domain (Ig); short basic domain; secreted; (semaphorin) 3E | cell differentiation, cell motility, multicellular organismal development, nervous system development | serine-type endopeptidase inhibitor activity |