Table 2.
Relationships between SERPINB5 expression and clinicopathological factors in rectal cancer patients receiving preoperative CCRT
| Parameter | No. (%) | SERPINB5 Expression | P-value | ||
|---|---|---|---|---|---|
| Low Exp | High Exp. | ||||
| Gender | Male | 108 (62.8) | 55 | 53 | 0.752 |
| Female | 64 (37.2) | 31 | 33 | ||
| Age | <70 | 106 (61.6) | 53 | 53 | 1.000 |
| ≥70 | 66 (38.4) | 33 | 33 | ||
| Pre-CCRT T stage | T1-T2 | 81 (47.1) | 43 | 38 | 0.445 |
| T3-T4 | 91 (52.9) | 43 | 48 | ||
| Pre-CCRT N stage | N0 | 125 (72.7) | 72 | 53 | <0.001* |
| N1-N2 | 47 (27.3) | 14 | 33 | ||
| Pre-CCRT CEA | ≤5 ng/ml | 114 (66.3) | 62 | 52 | 0.107 |
| >5 ng/ml | 58 (33.7) | 24 | 34 | ||
| Post-CCRT T stage | yT0-yT2 | 86 (50.0) | 54 | 32 | 0.001* |
| yT3-yT4 | 86 (50.0) | 32 | 54 | ||
| Post-CCRT N stage | yN0 | 123 (71.5) | 77 | 46 | <0.001* |
| yN1-yN2 | 49 (28.5) | 9 | 40 | ||
| Lymphovascular invasion | Absent | 157 (91.3) | 83 | 74 | 0.015* |
| Present | 15 (8.7) | 3 | 12 | ||
| Perineural invasion | Absent | 167 (97.1) | 85 | 82 | 0.173 |
| Present | 5 (2.9) | 1 | 4 | ||
| Tumor regression grade | Grade 0-1 | 37 (21.5) | 10 | 27 | <0.001* |
| Grade 2-3 | 118 (68.6) | 61 | 57 | ||
| Grade 4 | 17 (9.9) | 15 | 2 | ||
*, statistically significant