Table 2.
Selected parameters used in the Initiator Titration Model.
| Input variables | Calculated numbers | ||
|---|---|---|---|
| τ | Doubling time | V | Cell volume |
| C | Replication time | T | Age of cells |
| D | Time from termination to cell division | Tn's | Replication fork positions |
| Ai | Number of DnaA molecules required for initiation | n | DnaA boxes per growing cell |
| KD | Dissociation constant for DnaA-DnaA box interaction | G | Genome equivalents per cell |
| kdnaA1p | Promoter constant dnaA1p (3)a | g | dnaA genes per cell |
| kdnaA2p | Promoter constant dnaA2p (15)a | A | DnaA proteins per cell |
| kdnaAcp | Promoter constant dnaA constitutive component (3)a | m | dam genes per cell |
| kdam | Promoter constant damP (0.5)a | δ | Fraction of time the dnaA promoters are open (calculated using KD, A, n, V) |
a
The numbers in parentheses are relative promoter activities.