Table 5.
Estimated incremental cost | p value | Estimated incremental QALYs | p value | ICER, £ per QALY | |
---|---|---|---|---|---|
Primary analysis | |||||
QALYs | £1266 (736 to 1796) | <0·0001 | 0·034 (−0·004 to 0·065) | 0·13 | £36 812 |
Secondary analysis | |||||
Hospital attendance for repeated self-harm event | £1253 (725 to 1780) | <0·0001 | 0·033 (−0·130 to 0·197)* | 0·98 | Family therapy less effective and more costly than treatment as usual (family therapy is a dominated option)† |
Sensitivity analyses | |||||
Bootstrapped average (10 000 replications)‡ | £1255 (1149 to 1260) | <0·0001 | 0·034 (0·034 to 0·034) | 0·03 | £36 706 |
Assumption of only one therapist involved in each session in the family therapy group‡ | £1380 (748 to 2013) | <0·0001 | 0·034 (−0·004 to 0·065) | 0·13 | £40 130 |
Assumption of average number of therapists involved in each treatment session in the family therapy group‡ | £1546 (910 to 2183) | <0·0001 | 0·034 (−0·004 to 0·064) | 0·14 | £44 956 |
Adjustment for baseline EQ-5D-3L differences‡ | £1266 (736 to 1796) | <0·0001 | 0·039 (0·035 to 0·042) | 0·03 | £32 852 |
Complete case | £1135 (267 to 2538) | <0·0001 | −0·003 (−0·086 to 0·080) | 0·91 | Family therapy less effective and more costly than treatment as usual (family therapy is a dominated option) |
Including caregivers' QALYs‡ | £1207 (662 to 1752) | <0·0001 | 0·058 (0·002 to 0·114) | 0·04 | £20 808 |
All results are estimates for family therapy versus treatment as usual (95% CI). QALY=quality-adjusted life-year. ICER=incremental cost-effectiveness ratio.
Incremental number of self-harm events estimate (95% CI).
ICER, £ per self-harm event.
With multiple imputation.