Figure 1.

Major tolerogenic signatures upregulated on CCR7⁺ steady-state migratory dendritic cells (ssmDCs). Selected tolerogenic transcripts of IL12b, RelB, Socs2, Cd200, Cd274, and Ccl5 are upregulated in CCR7⁺ ssmDCs (CD103⁺ migDC, CD11b⁺ migDC, Langerhans cells) as compared to CCR7⁻ resident DC subsets (CD8⁺ resDCs, CD4⁺ resDCs) or plasmacytoid DCs (pDCs). Data were obtained from the Immgen database (http://www.immgen.org/).