Table 1.
Tolerogenic genes upregulated more than log2-fold by DCs matured during steady state, inflammation, or by pathogens.
| Gene name | XCR1 + ssmDCs (15) | ssmDCs (14) | spont. mat. BM-DCs (19) | ImmGen data base | LPS (20) | LPS (21) | TNF (22) | LPS (22) | CT (23) | Mtb (24–26) | Nippostrongylus brasiliensis(27) | Brugia malayi(24) | Schistosoma mansonii(28) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Il12b | Up | Up | Up | Up | Up | Up | Up | Up | |||||
| RelB | Up | Up | Up | Up | Up | Up | Up | Up | |||||
| Ccl5 | Up | Up | Up | Up | Up | Up | |||||||
| Socs2 | Up | Up | Up | Up | Up | ||||||||
| CD83 | Up | Up | Up | Up | Up | Up | |||||||
| Cd150 (Slamf1) | Up | Up | Up | Up | Up | Up | |||||||
| Cd200 | Up | Up | Up | Up | Up | ||||||||
| Cd274 | Up | Up | Up | Up | |||||||||
| Aldh1a2 (Raldh2) | Up | Up | Up | ||||||||||
| Slamf7 | Up | Up | Up | ||||||||||
| Inhba | Up | Up | Up | ||||||||||
| Ido1 | Up | Up | |||||||||||
| Adora2a | Up | Up | |||||||||||
| IL-27 | Up | Up | |||||||||||
| Tgfb2 | Up | ||||||||||||
| Itgb8 | Up | ||||||||||||
| Optn | Up | ||||||||||||
| Thbs1 | Up | ||||||||||||
| Vegfa | Up | ||||||||||||
| HLA-G | Up |
Steady-state migratory DCs/spontaneously matured BM-DCs.
LPS/TNF/CT-matured DCs.
Mycobacteria-matured DCs.
Helminth-matured DCs.