Table 2.
Gene nameHuman/mouse, protein name | Functions | References for tolerogenicity |
---|---|---|
IL12B/IL12b IL-12p40 |
p40 homodimer antagonizes IL-12p70 | (29, 30) |
IDO1/Ido1 Indoleamine-2,3-dioxigenase IDO |
Metabolic inhibition of T cell proliferation by l-tryptophan catabolism | (31, 32) |
Cd150/SLAMF1/Slamf1 CD150/SLAM |
Receptor for measles virus, inhibitor of DC function | (33–37) |
INHBA/Inhba Inhibin βA, Activin βA |
Partially inhibits DC maturation. Synergizes with TGF-β for induction of Foxp3+ Tregs | (38, 39) |