Table 5.

Tolerogenic transcripts induced specifically by TNF (human and mouse data from Figure 2) and for which anti-inflammatory or tolerogenic functions have been reported.

Gene nameHuman/mouse, Protein name	Tolerogenic functions	References for tolerogenicity
Cd200	Immune regulatory in placenta, in pDC for IDO production and by pathogens	(49–51)
ALDH1A2/Aldh1a2 (Raldh2)	Coinducer with TGF-β or IL-4 for induction of Foxp3+ Tregs	(52, 53)
RelB	Expressed in self-antigen presenting, Treg inducing steady-state migratory DCs	(14, 16)
CD83	Secreted soluble CD83 induces Tregs, prevents T cell activation, and is highly tolerogenic in autoimmunity and allogeneic transplantation models	(54–58)