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. 2017 Dec 8;28(3):265–280. doi: 10.1038/cr.2017.155

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Copyright © 2017 The Author(s)

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Mitochondrial metabolism in malignant transformation. Mitochondrial dysfunction can promote malignant transformation, i.e., the conversion of a healthy cell into a malignant precursor, as a consequence of (1) reactive oxygen species (ROS) overgeneration, which favors mutagenesis; (2) accumulation of succinate, fumarate or 2-hydroxyglutarate (all of which can operate as oncometabolites, at least in some settings); and/or (3) increased resistance to oncogene-driven mitochondrial outer membrane permeabilization (MOMP)- or mitochondrial permeability transition (MPT)-driven regulated cell death or cellular senescence.