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. 2017 Dec 8;28(3):265–280. doi: 10.1038/cr.2017.155

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Mitochondrial metabolism and oncogenesis. Mitochondria have a major impact on virtually all processes linked to oncogenesis, encompassing malignant transformation, tumor progression, response to treatment and anticancer immunosurveillance. C, cancer cell; D, dying cancer cell; L, lymphocyte; M, metastatic cancer cell; mtDNA, mitochondrial DNA; MOMP, mitochondrial outer membrane permeabilization; MPT, mitochondrial permeability transition; N, normal cell; OXPHOS, oxidative phosphorylation; R, resistant cancer cell; ROS, reactive oxygen species; TME, tumor microenvironment.