. 2018 Feb 16;28(3):296–306. doi: 10.1038/cr.2018.17

Table 2. Role of Ca²⁺ in the etiology of SCA.

Type of SCA	Protein	Effect on Ca²⁺ homeostasis	References
SCA1	Ataxin 1	Reduction of PC Ca²⁺-binding protein levels	^79,80
SCA2	Ataxin 2	Increase Ca²⁺ release from ER stores	^81,82
SCA3	Ataxin 3	Increase Ca²⁺ release from ER stores	⁸³
SCA5	β-III-spectrin	Increase	⁸⁴
SCA6	CACNA1A	Impaired Ca²⁺ flux into neurons	⁸⁵
SCA14	PKCγ	Increase/Decrease	⁸⁶
SCA15	ITPR1	Inositol 1,4,5-triphosphate Ca²⁺ signaling	⁸⁷
SCA28	AFG3-like protein 2	MCU complex assembly	⁴⁷

CACNA1A, Ca²⁺ voltage-gated channel subunit alpha1 A; PKCγ, protein kinase C subunit γ ITPR1, inositol 1,4,5-trisphosphate receptor type 1; SCA, spinocerebellar ataxias.

Table 2. Role of Ca2+ in the etiology of SCA.

Table 2. Role of Ca²⁺ in the etiology of SCA.