Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 12;28(3):323–335. doi: 10.1038/cr.2018.2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Eos-dependent HSC impairment in IL-5 Tg mice. (A) Quantification of LSKs from the BM of WT and IL-5 Tg mice. (B, C) Representative FACS plots and quantification of LT-HSCs, ST-HSCs and MPP-HSCs from the BM. (D, E) Absolute numbers of progenitor cells in the BM. (F) Percentage of donor-derived peripheral blood (PB) cells at 4, 8 and 12 weeks after competitive LSK transplantation. (G) Percentage of donor-derived total BM cells and LSKs after 12 weeks of reconstitution in competitive BM transplants. (H, I) Absolute numbers of LSKs in the BM (H) and SP (I). (J, K) Changes in spleen appearances: long diameter and weight ratio with body weight. Data are shown as the means ± SEM with six samples per group. ^**P < 0.01, ^***P < 0.001 versus respective controls. CLP, common lymphoid progenitors; CMP, common myeloid progenitors; GMP, granulocyte/monocyte lineage progenitors; MEP, megakaryocyte/erythroid progenitors.