Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 12;28(3):323–335. doi: 10.1038/cr.2018.2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Eos-derived CCL-6 is responsible for disrupted HSC homeostasis. (A) Heatmap of screened cytokines and chemokines in bone marrow supernatants of WT, IL-5 Tg, Eos-null mice analyzed by mass spectroscopy. (B) CCL-6 MFI analysis by FACS in Eos and Neu from IL-5 Tg mice. (C) CCL-6 levels determined by ELISA in the serum of WT, IL-5 Tg, Eos-null and IL-5 Tg and Eos-null mice. Cons, concentrations. (D) CCL-6 MFI analysis by FACS in Eos and Neu from OVA-challenged and control mice. (E) CCL-6 levels determined by ELISA in the serum of OVA-challenged and control mice. (F) ROS MFI analysis in LT-HSCs co-cultured with Eos transfected with negative control siRNA (NC) or Ccl-6 siRNA for 2 h. (G) HSC migration assay after co-culture for 12 h with Eos transfected with NC or Ccl-6 siRNA. (H) ROS MFI analysis in HSCs co-cultured for 2 h with Eos following treatment with BX471. Data are shown as the means ± SEM with six samples per group. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 versus respective controls.