Table 4.
Pathway enrichment analysis for DEGs (top five pathways)
| KEGG ID | Pathway | Count | P-value | Genes |
|---|---|---|---|---|
| Up-regulated DEGs | ||||
| hsa04713 | Circadian entrainment | 9 | 0.01347155 | GNAO1, ADCY2, PLCB4, NOS1AP, GRIN2A, GUCY1A3, ADCY10, CAMK2A, PLCB2 |
| hsa05204 | Chemical carcinogenesis | 8 | 0.016721213 | CYP3A4, CYP3A5, CYP1B1, ADH4, KYAT1, CYP1A2, GSTM5, UGT2B28 |
| hsa04514 | Cell adhesion molecules (CAMs) | 11 | 0.019733043 | ALCAM, SIGLEC1, SDC1, CLDN19, NFASC, CTLA4, NLGN2, MADCAM1, CLDN10, HLA-DMB, SPN |
| hsa04080 | Neuroactive ligand-receptor interaction | 17 | 0.021992572 | GPR156, F2RL2, GABRB2, NPY2R, DRD5, LHCGR, GABRA5, GRIN2A, BRS3, PLG, P2RY4, LPAR6, S1PR4, HTR6, AVPR1B, HTR2A, GRID1 |
| hsa00982 | Drug metabolism-cytochrome P450 | 7 | 0.025033146 | CYP3A4, CYP3A5, ADH4, FMO2, CYP1A2, GSTM5, UGT2B28 |
| Down-regulated DEGs | ||||
| hsa04141 | Protein processing in endoplasmic reticulum | 33 | 1.25×10-7 | RAD23B, TRAF2, SEC24B, DERL2, GANAB, PDIA3, RAD23A, RNF185, PDIA6, EDEM3, LMAN1, SEC62, EDEM1, SEC63, SSR1, STT3B, BAK1, ERO1A, HSPA6, YOD1, HSPA5, RPN2, SEC61A1, SEC23A, P4HB, MAN1A1, HYOU1, BAX, SIL1, NFE2L2, PPP1R15A, EIF2AK3, SEL1L |
| hsa04142 | Lysosome | 26 | 5.64×10-7 | GNPTG, GM2A, ATP6AP1, LGMN, CTSA, TPP1, GALC, MCOLN1, IDUA, TCIRG1, LAPTM4B, LAPTM4A, LIPA, PSAP, GUSB, CD164, M6PR, CTSV, GNS, LAMP1, LAMP2, IGF2R, SUMF1, CTSD, NEU1, ATP6V0A2 |
| hsa04110 | Cell cycle | 25 | 3.25×10-6 | MAD1L1, CREBBP, ATR, WEE1, MCM5, TGFB1, CDC25B, MCM6, CDC45, CDKN1B, CDKN2B, CDKN2C, PLK1, CDKN2D, GADD45G, TFDP2, PCNA, SMC1A, CCNA1, GADD45B, ORC1, MYC, CCNA2, ORC2, ORC3 |
| hsa05169 | Epstein-Barr virus infection | 27 | 6.01×10-4 | TRAF2, NFKBIE, POLR2D, POLR2B, AKT1, IL10RB, HSPA6, CCNA1, CCNA2, MYC, TRAF5, SYK, PIK3CG, CREBBP, HLA-A, HLA-C, POLR3A, HLA-B, HLA-G, TYK2, CDKN1B, PSMC4, PSMD11, MAPK14, CD58, IKBKB, EIF2AK3 |
| hsa03430 | Mismatch repair | 8 | 6.79×10-4 | POLD4, MSH6, RFC3, RFC2, MSH2, LIG1, POLD1, PCNA |