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ZG reduces blood serum concentration of OA biomarkers. The serum concentration levels of the OA biomarkers in DMM mice were significantly lower in the treatment group (ZG) compared with the normal saline group (NS) (P<0.05) with the exception of MMP-13, where no significant difference was noted. (n=8 mice per time point). TNF-α (A), COMP (B), CTX-1 (C), and MMP-13 (D). *P<0.05, **P<0.01, ***P<0.001, n.s, not statistically significant.
