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ZG reduces the expression of OA biomarkers and promotes chondrocyte matrix production. The measurement of cell biomarkers and cartilaginous matrix components was conducted by qPCR. (A) The expression levels of the biomarkers collagen II, Aggrecan, MMP-1, MMP-3, MMP-13 and ADAMTS5 mRNA were evaluated in chondrocytes. (A) Collagen II, (B) Aggrecan, (C) MMP-3, (D) MMP-13, (E) ADAMTS5. *P<0.05, **P<0.01, ***P<0.001, n.s, not statistically significant.
