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. 2018 Feb 15;10(2):455–464.

Figure 2.

Figure 2

Knockout of PLAC8 decreases proliferation and reduces the surviving fraction after irradiation in CNE2 cells. A, B: CCK-8 assay of the number of surviving PLAC8(+) and PLAC8(-) cells at 24, 48 and 72 h after 6 Gy irradiation. Knockout of PLAC8 significantly reduced the survival of both non-irradiated and irradiated CNE2 cells compared to PLAC8(+) cells at all time-points. All quantitative data shown represent the means ± SD of 3 independent replicates; significant differences were shown as *P < 0.05. C, D: IR-PLAC8(-) cells had significantly lower surviving fractions compared to IR-PLAC8(+) cells after irradiation at 2, 4, 6 and 8 Gy. E: The proliferation of IR-PLAC8(-) cells was significantly suppressed compared to IR-PLAC8(+) cells after irradiation at 24 h and 48 h.