Table 1.
MTS assay of candidate genes selected for siRNA screening
| Candidate genes selected for siRNA screening with MTS assay results | |||||
|---|---|---|---|---|---|
| ID | Gene symbol | Basis for selectiona | MTS assay (siRNA KD)b | ||
| Integrated analysis (SNP vs. Exp. P < 10−4)(Exp. vs. IC50. P < 10−3) | Gene set analysis | SU86 | BT549 MDA‐MB‐231 | ||
| 1 | RIT1 | – | Yes | – | – |
| 2 | ZNF544 | – | Yes | – | – |
| 3 | VEZT | – | Yes | Yes | Yes |
| 4 | JMJD3 | – | Yes | – | – |
| 5 | AHCYL1 | – | Yes | – | – |
| 6 | FAM32A | – | Yes | – | – |
| 7 | DCLRE1A | Yes | – | Yes | – |
| 8 | TAGLN2 | Yes | – | – | – |
| 9 | GOLGA8B | Yes | – | Yes | Yes |
| 10 | LRRC47 | Yes | – | – | – |
| 11 | SEMA4A | Yes | – | – | – |
| 12 | NFIL3 | Yes | – | Yes | – |
| 13 | PIGS | Yes | – | – | – |
| 14 | MOV10 | Yes | – | – | – |
| 15 | CAB39 | Yes | – | – | – |
| 16 | GLOD4 | Yes | – | – | – |
| 17 | SLC7A5 | Yes | – | Yes | Yes |
| 18 | ERRFI1 | Yes | – | Yes | Yes |
Eighteen genes selected for siRNA screening are listed.
a
“Yes'' indicates individual candidate genes with the P‐value listed.
b
“Yes'' indicates that knockdown of the gene altered TCN cytotoxicity (IC50 values) when compared with control siRNA. “–'' indicates that knockdown of the gene did not alter TCN cytotoxicity (IC50 values) when compared with control siRNA.