Table II.
Association between RECQL4 mRNA expression, clinical parameters and disease-free/overall survival.
| Disease-free survival | Overall survival | ||||||
|---|---|---|---|---|---|---|---|
| Clinical characteristics | Patients, n | Mean, months | 95% CI | P-value | Mean, months | 95% CI | P-value |
| RECQL4 mRNA | 0.002 | 0.001 | |||||
| Low | 64 | 50.73 | 41.88–59.58 | 56.31 | 48.33–64.30 | ||
| High | 141 | 34.23 | 28.42–40.03 | 38.37 | 32.84–43.90 | ||
| Age, years | 0.646 | 0.634 | |||||
| ≤55 | 138 | 38.09 | 32.06–44.11 | 43.70 | 37.84–49.57 | ||
| >55 | 67 | 40.68 | 32.17–49.19 | 45.85 | 37.62–54.08 | ||
| Sex | 0.299 | 0.141 | |||||
| Female | 33 | 45.30 | 31.98–58.63 | 53.41 | 41.20–65.62 | ||
| Male | 172 | 37.82 | 32.53–43.10 | 42.81 | 37.63–47.50 | ||
| Family history | 0.155 | 0.115 | |||||
| No | 172 | 37.20 | 31.90–42.50 | 42.85 | 37.65–48.06 | ||
| Yes | 33 | 48.00 | 35.61–60.39 | 53.12 | 41.56–64.68 | ||
| Alcohol consumption | 0.139 | 0.081 | |||||
| No | 101 | 43.60 | 36.17–51.04 | 48.07 | 41.02–55.13 | ||
| Yes | 104 | 34.88 | 28.50–41.26 | 40.51 | 34.20–46.81 | ||
| HBsAg | 0.652 | 0.616 | |||||
| Negative | 41 | 35.44 | 25.01–45.87 | 41.84 | 31.60–52.09 | ||
| Positive | 164 | 39.74 | 34.18–45.30 | 44.61 | 39.30–49.93 | ||
| AFP, ng/ml | 0.200 | 0.209 | |||||
| ≤100 | 75 | 42.88 | 35.17–50.58 | 48.09 | 40.94–55.24 | ||
| >100 | 130 | 37.19 | 30.73–43.65 | 41.20 | 35.06–47.34 | ||
| Cirrhosis | 0.694 | 0.824 | |||||
| No | 20 | 35.40 | 19.79–51.01 | 41.85 | 27.14–56.56 | ||
| Yes | 185 | 39.23 | 34.05–44.14 | 44.24 | 39.27–49.21 | ||
| Tumor size, cm | <0.001 | <0.001 | |||||
| ≤6 | 89 | 57.76 | 50.66–64.85 | 62.66 | 56.55–68.77 | ||
| >6 | 116 | 25.25 | 19.59–30.91 | 29.59 | 24.04–35.14 | ||
| Tumor number | <0.001 | <0.001 | |||||
| Single | 137 | 44.85 | 38.77–50.92 | 50.84 | 45.03–56.65 | ||
| Multiple | 68 | 26.57 | 19.03–34.11 | 31.75 | 24.25–39.25 | ||
| BCLC stage | <0.001 | <0.001 | |||||
| 0-A | 92 | 54.29 | 47.04–61.54 | 60.09 | 53.47–66.72 | ||
| B-C | 113 | 26.41 | 20.70–32.12 | 31.76 | 25.94–37.58 | ||
| Metastasis | 0.023 | 0.048 | |||||
| No | 176 | 41.15 | 35.76–46.53 | 45.63 | 40.51–50.75 | ||
| Yes | 29 | 23.56 | 14.71–32.42 | 34.12 | 22.84–45.39 | ||
| Recurrence | <0.001 | ||||||
| No | 135 | 34.55 | 28.81–40.28 | ||||
| Yes | 70 | 63.22 | 56.70–69.75 | ||||
CI, confidence interval; HBsAg, hepatitis B surfaceantigen; AFP, alpha-fetoprotein; BCLC, Barcelona Clinic Liver Cancer; Metastasis, distant metastasis or lymph node metastasis; RECQL4, ATP-dependent DNA helicase Q4.