Table III.

Cox multivariate proportional hazards model of independent predictors on disease-free and overall survival.

A, Disease-free survival
Parameter	HR (95% CI)	P-value
Tumor size, cm (≤6 vs. >6 cm)	2.670 (1.704–4.183)	<0.001
Tumor number (single vs. multiple)	1.092 (0.692–1.723)	0.707
Metastasis (no vs. yes)	1.116 (0.685–1.816)	0.660
BCLC stage (0-A vs. B-C)	1.835 (1.116–3.018)	0.017
RECQL4 mRNA (low vs. high)	1.635 (1.062–2.515)	0.025
B, Overall survival
Parameter	HR (95% CI)	P-value
Tumor size, cm (≤6 vs. >6 cm)	2.536 (1.621–3.967)	<0.001
Tumor number (single vs. multiple)	1.033 (0.652–1.637)	0.890
Metastasis (no vs. yes)	1.212 (0.742–1.981)	0.443
BCLC stage (0-A vs. B-C)	1.679 (1.021–2.760)	0.041
Recurrence (no vs. yes)	2.832 (1.827–4.391)	<0.001
RECQL4 mRNA (low vs. high)	1.618 (1.050–2.493)	0.029

HR, hazard ratio; CI, confidence interval; metastasis, distant metastasis or lymph node metastasis; BCLC, Barcelona Clinic Liver Cancer; RECQL4, ATP-dependent DNA helicase Q4.