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. 2018 Jan 22;15(4):4255–4261. doi: 10.3892/ol.2018.7840

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Pancreatic neuroendocrine tumors are characterized by endothelial cell detachment. (A-C) H&E staining of an insulinoma sample with blood-filled caverns unlined and lined by endothelial cells. (B and C) Higher magnification of blood-filled caverns presented in (A). a, Blood-filled cavern lined by endothelial cells; b, blood-filled cavern partially lined by endothelial cells; c, blood-filled cavern unlined by endothelial cells linked to normal vasculature (white arrows). (D and E) H&E staining of two different insulinoma samples with endothelial cells detached from the surrounding tumor cells. (F) H&E staining of a gastrinoma sample with endothelial cells detached from the surrounding tumor cells. The boxed area is presented at a 2-fold higher magnification in the lower left corner. Endothelial cells are indicated by arrows and the filamentous cell-cell connections are indicated by arrowheads. Scale bar, 25 µm. H&E, hematoxylin and eosin.