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. 2018 Jan 22;15(4):4255–4261. doi: 10.3892/ol.2018.7840

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Blood-filled caverns unlined by endothelial cells generated in an INS-1 xenograft insulinoma model. A total of 10⁶ INS-1 cells were subcutaneously injected into nude mice. Xenograft insulinoma tumors were harvested 2–3 weeks later. (A and B) An insulinoma tumor observed under a stereomicroscope. (A) The tumor has a bloody appearance and intact envelope. (B) Multiple hemorrhagic spots are observed under higher magnification. Scale bar, 500 µm. (C and D) Hematoxylin and eosin staining of paraffin slides of INS-1 tumors. (C) Numerous blood-filled caverns can be observed in the slide. (D) The blood-filled caverns are unlined by endothelial cells as presented in higher magnification. Scale bar, 50 µm.