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. 2018 Jan 22;15(4):4255–4261. doi: 10.3892/ol.2018.7840

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Blood-filled caverns unlined by endothelial cells in INS-1 tumors are distinct from vasculogenic mimicry. (A) PAS staining of INS-1 tumors. (B) CD31 staining of INS-1 tumors. PAS and CD31 staining was positive for normal blood vessels and negative for tumor cells lining the blood-filled caverns unlined by endothelial cells (marked by asterisks). Signals of endothelial cells are marked by black arrows. Certain blood-filled caverns were directly linked to normal vasculature (white arrows). (C) Laminin staining of INS-1 tumors. Laminin staining was negative in the internal face of the lining tumor cells. Only a fragment of laminin-positive staining was able to be observed in a specific blood-filled cavern (arrow). Scale bar, 50 µm. PAS, periodic acid-Schiff.