Table I.
Characteristics of participants and gene methylation.
| Variable | NC (n=28) | LSIL (n=32) | HSIL (n=34) | CSCC (n=27) | P-value |
|---|---|---|---|---|---|
| Age, years | 36.2±7.7 | 28.3±7.6 | 39.7±10.5 | 44.4±8.8 | 0.006 |
| HPV-negative | 18 | 6 | 3 | 2 | <0.001 |
| High-risk HPV | 10 | 26 | 31 | 25 | |
| HPV DNA | 89.85±95.77 | 480.23±702.79 | 630.28±623.75 | 1650.80±4595.88 | 0.23 |
| PAX1 in tissue | 4.92±4.45 | 5.55±5.05 | 10.21±14.39 | 41.97±23.02 | <0.001 |
| PAX1 in exfoliated cell | 4.57±2.43 | 3.38±2.36 | 13.64±13.35 | 26.38±18.53 | <0.001 |
| LMX1A in tissue | 4.53±3.76 | 5.05±3.06 | 4.70±5.12 | 14.36±18.31 | <0.001 |
| LMX1A in exfoliated cell | 2.15±1.26 | 3.35±1.89 | 5.66±2.60 | 9.18±12.1 | <0.001 |
| TCT, n | <0.001 | ||||
| Normal (NC) | 20 | 7 | 4 | 5 | |
| Low (CIN1) | 1 | 6 | 2 | 1 | |
| High (CIN2-3) | 1 | 1 | 17 | 18 | |
| ASC-US | 6 | 18 | 11 | 1 | |
| CSCC | 0 | 0 | 0 | 2 |
Values are in n, unless otherwise stated. NC, normal cervix; LSIL, low-grade squamous intraepithelial lesion; HSIL, high-grade squamous intraepithelial lesion; CSCC, cervical squamous-cell carcinoma; HPV, human papilloma virus; PAX1, paired box gene 1; LMX1A, LIM homeobox transcription factor 1 α; LMX2A, LIM homeobox transcription factor 2 α; TCT, thin-layer liquid-based cervical cytology; CIN, cervical intraepithelial neoplasia; ASC-US, atypical squamous cells of undetermined significance.