Table IV.
In vitro ELISPOT assay prior to the initiation of therapy and following 2 cycles of treatment in the human leukocyte antigen-A2402 matched group.
| CTL response (RNF43/TOMM34) | ||
|---|---|---|
| Patient no. | Prior to the initiation of therapy | Following 2 cycles of therapy |
| 1 | +/+ | NA/NAa |
| 2 | −/− | −/NAa |
| 3 | −/+ | −/+ |
| 4 | −/− | +/− |
| 5 | −/+ | −/− |
| 6 | −/− | NA/NAa |
| 7 | +/− | +/− |
| 8 | −/− | +/− |
| 9 | −/− | −/+ |
| 10 | −/− | −/− |
| 11 | −/− | +/− |
| 12 | −/− | −/− |
| 13 | +/− | +/− |
| 14 | +/− | −/+ |
| 15 | −/− | −/− |
| 16 | −/− | +/− |
| 17 | +/NA | +/+ |
| 18 | −/NA | −/− |
| 19 | −/− | −/− |
| 20 | −/− | −/− |
| 21 | −/− | −/− |
| 22 | +/+ | −/NAa |
| 23 | −/− | +/NA |
| 24 | −/NA | −/− |
| 25 | −/− | −/+ |
| 26 | +/− | +/− |
| 27 | +/− | −/+ |
| 28 | −/− | −/NAa |
a
The CTL responses of 5 patients were not detected and thus, were excluded from the analysis. NA, not available; CTL, cytotoxic T lymphocyte; RNF43, ring finger protein 43; TOMM34, 34-kDa translocase of the outer mitochondrial membrane.