Table I.

A listing of clinical trials of oncolytic viruses provided by a previous review (1).

Virus family	Genetic modifications	Target types of cancer	Clinic trial sponsor
Adenovirus
Oncorine (H101)	Ad-E1b−	Liver, lung, head/neck and pancreas	Shanghai Sunway (approved in China)
CGTG-102	Ad-GMCSF+	Solid tumors	Oncos
DNX-2401	Ad-d24RGD	Brain	DNAtrix/Erasmus Medical Center
ICOVIR-5	Ad-DM-E2F-K-d24RGD	Melanoma	Institut Catala d'Oncologia
CG0070	Ad-GMCSF+	Bladder	Cold Genesys
Colo Ad1	Ad3:Ad11p hybrid	Metastatic solid tumors	PsiOxus
Herpesvirus
T-VEC	HSV1-ICP34.5−/4−GMCSF+	Melanoma	Amgen/BioVex (completed Phase III)
Seprehvir	HSV1716-ICP34.5−	Lung, various solid tumors	Virttu Biologics and Children's Hospital
G207	HSV1-ICP34.5−/6−	Brain	MediGene
HF10	HSV-HF strain	Head/neck, skin, breast and melanoma	Takara Bio
Poxvirus
Pexa-Vec/JX594	Vaccinia Wyeth TK−/GMCSF+	Liver, colorectal, head/neck, others	Jennerex (multiple trials)
Paramyxovirus
Measles virus	MV-NIS+, MV-CEA+	Ovarian, peritoneal, myeloma, others	Mayo Clinic/NCI (multiple trials)
Newcastle disease virus	Natural isolate (HUJ)	Glioblastoma multiforme, neuroblastoma, sarcomas	Hadassah Medical Organization
Reovirus
Reolysin	Reovirus-serotype 3	Diverse types of cancer	Oncolytics Biotech Inc. (multiple trials)
Rhabdovirus
Vesicular somatitis virus	VSV-IFNb+	Hepatocellular carcinoma	Mayo Clinic
Maraba virus	MAGE A3+/Matrix glycoprotein mutations	Lung, colon, melanoma	NCIC Clinical Trials Group
Picornavirus
CAVATAK	Coxsackievirus-A21	Melanoma	Viralytics (multiple trials)
PVS-RIPO	Polio:Rhinovirus chimera	Glioblastoma	Duke University
Seneca Valley V.	Natural isolate (NTX-010)	Neuroendocrine tumors	Children's Oncology Group
Parvovirus
H-1 PV	Natural isolate	Glioblastoma	Heidelberg University Hospital