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. 2018 Jan 31;15(4):4926–4936. doi: 10.3892/ol.2018.7911

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Copyright: © Cho et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Kaplan-Meier analysis of the association between Hippo pathway genes and overall survival. In order to investigate the Hippo pathway, survival was studied against levels of (A) YAP1 mRNA, (B) YAP1 protein and (C) pYAP1 protein. The mRNA levels of (D) TAZ, (E) TEAD1, (F) TEAD2, (G) TEAD3, (H) TEAD4, (I) MST1, (J) MST2, (K) LATS1 and (L) LATS2 were also assessed. Cutoff Finder was used to determine cut-off values in mRNA and protein expression of colon adenocarcinoma using log-rank tests. mRNA of YAP1, TAZ, TEAD4 and LATS2 exhibited the poor prognosis. YAP1, yes-associated protein 1; pYAP, phosphorylated form of YAP1; TAZ, taffazin; TEAD, transcriptional enhancer associated domain; MST, macrophage stimulating; LATS, large tumor suppressor kinase.