Table III.
DAVID analysis of ClassNeighbors.
| A, Class A | |||
|---|---|---|---|
| Term | Count | % | P-value |
| Biological process | |||
| GO: 0030178-Negative regulation of Wnt signaling pathway | 6 | 4.5 | <0.01 |
| GO: 0001942-Hair follicle development | 4 | 3.0 | <0.01 |
| GO: 0001580-Detection of chemical stimulus involved in sensory perception of bitter taste | 4 | 3.0 | <0.01 |
| GO: 0007275-Multicellular organism development | 11 | 8.2 | <0.01 |
| GO: 0090090-Negative regulation of canonical Wnt signaling pathway | 6 | 4.5 | <0.01 |
| GO: 0016055-Wnt signaling pathway | 6 | 4.5 | 0.01 |
| GO: 0035019-Somatic stem cell population maintenance | 4 | 3.0 | 0.01 |
| GO: 0060279-Positive regulation of ovulation | 2 | 1.5 | 0.01 |
| GO: 0046882-Negative regulation of follicle-stimulating hormone secretion | 2 | 1.5 | 0.02 |
| GO: 0007411-Axon guidance | 5 | 3.7 | 0.02 |
| GO: 0009653-Anatomical structure morphogenesis | 4 | 3.0 | 0.02 |
| GO: 0070858-Negative regulation of bile acid biosynthetic process | 2 | 1.5 | 0.03 |
| GO: 0030154-Cell differentiation | 8 | 6.0 | 0.04 |
| GO: 0001755-Neural crest cell migration | 3 | 2.2 | 0.04 |
| GO: 0042423-Catecholamine biosynthetic process | 2 | 1.5 | 0.04 |
| GO: 0046881-Positive regulation of follicle-stimulating hormone secretion | 2 | 1.5 | 0.04 |
| GO: 0010862-Positive regulation of pathway-restricted SMAD protein phosphorylation | 3 | 2.2 | 0.04 |
| GO: 0009072-Aromatic amino acid family metabolic process | 2 | 1.5 | 0.05 |
| GO: 0021516-Dorsal spinal cord development | 2 | 1.5 | 0.05 |
| GO: 0000122-Negative regulation of transcription from RNA polymerase II promoter | 10 | 7.5 | 0.05 |
| GO: 0010470-Regulation of gastrulation | 2 | 1.5 | 0.05 |
| Cellular component | |||
| GO: 0005576-Extracellular region | 24 | 17.9 | <0.01 |
| GO: 0005615-Extracellular space | 21 | 15.7 | <0.01 |
| GO: 0016324-Apical plasma membrane | 7 | 5.2 | 0.01 |
| GO: 0071944-Cell periphery | 3 | 2.2 | 0.03 |
| GO: 0005887-Integral component of plasma membrane | 17 | 12.7 | 0.03 |
| GO: 0009898-Cytoplasmic side of plasma membrane | 3 | 2.2 | 0.03 |
| Molecular function | |||
| GO: 0008083-Growth factor activity | 7 | 5.2 | <0.01 |
| GO: 0043565-Sequence-specific DNA binding | 10 | 7.5 | 0.01 |
| GO: 0003700-Transcription factor activity, sequence-specific DNA binding | 14 | 10.4 | 0.01 |
| GO: 0016714-Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen | 2 | 1.5 | 0.03 |
| GO: 0000981-RNA polymerase II transcription factor activity, sequence-specific DNA binding | 5 | 3.7 | 0.03 |
| GO: 0005160-Transforming growth factor beta receptor binding | 3 | 2.2 | 0.03 |
| GO: 0000978-RNA polymerase II core promoter proximal region sequence-specific DNA binding | 7 | 5.2 | 0.03 |
| KEGG | |||
| hsa04310: Wnt signaling pathway | 5 | 3.7 | 0.02 |
| hsa04350: TGF-β signaling pathway | 4 | 3.0 | 0.02 |
| hsa04970: Salivary secretion | 4 | 3.0 | 0.02 |
| hsa04530: Tight junction | 4 | 3.0 | 0.07 |
| hsa04550: Signaling pathways regulating pluripotency of stem cells | 4 | 3.0 | 0.07 |
| hsa04151: PI3K-Akt signaling pathway | 6 | 4.5 | 0.09 |
| B, Class B | |||
| Term | Count | % | P-value |
| Biological process | |||
| GO: 0071294-Cellular response to zinc ion | 7 | 5.0 | <0.01 |
| GO: 0045926-Negative regulation of growth | 7 | 5.0 | <0.01 |
| GO: 0071276-Cellular response to cadmium ion | 5 | 3.6 | <0.01 |
| GO: 0051453-Regulation of intracellular pH | 4 | 2.9 | <0.01 |
| GO: 0015701-Bicarbonate transport | 4 | 2.9 | <0.01 |
| GO: 0007586-Digestion | 4 | 2.9 | 0.01 |
| GO: 2001225-Regulation of chloride transport | 2 | 1.4 | 0.01 |
| GO: 0036018-Cellular response to erythropoietin | 2 | 1.4 | 0.01 |
| GO: 0032849-Positive regulation of cellular pH reduction | 2 | 1.4 | 0.03 |
| GO: 1902476-Chloride transmembrane transport | 4 | 2.9 | 0.03 |
| GO: 0006029-Proteoglycan metabolic process | 2 | 1.4 | 0.05 |
| GO: 0007189-Adenylate cyclase-activating G protein-coupled receptor signaling pathway | 3 | 2.1 | 0.05 |
| Cellular component | |||
| GO: 0005887-Integral component of plasma membrane | 19 | 13.6 | 0.01 |
| GO: 0048471-Perinuclear region of cytoplasm | 11 | 7.9 | 0.01 |
| GO: 0042589-Zymogen granule membrane | 2 | 1.4 | 0.08 |
| GO: 0005886-Plasma membrane | 38 | 27.1 | 0.08 |
| Molecular function | |||
| GO: 0008499-UDP-galactose:β-N-acetylglucosamine β-1,3-galactosyltransferase activity | 3 | 2.1 | <0.01 |
| GO: 0004623-Phospholipase A2 activity | 3 | 2.1 | 0.02 |
| GO: 0004957-Prostaglandin E receptor activity | 2 | 1.4 | 0.04 |
| GO: 0008270-Zinc ion binding | 15 | 10.7 | 0.04 |
| GO: 0005254-Chloride channel activity | 3 | 2.1 | 0.06 |
| GO: 0046983-Protein dimerization activity | 4 | 2.9 | 0.09 |
| GO: 0004089-Carbonate dehydratase activity | 2 | 1.4 | 0.10 |
| KEGG | |||
| hsa04978: Mineral absorption | 7 | 5.0 | <0.01 |
| hsa04972: Pancreatic secretion | 6 | 4.3 | <0.01 |
| hsa04975: Fat digestion and absorption | 4 | 2.9 | <0.01 |
| hsa04924: Renin secretion | 3 | 2.1 | 0.09 |
| hsa00830: Retinol metabolism | 3 | 2.1 | 0.10 |
DAVID, database for annotation, visualization and integrated discovery; KEGG, Kyoto Encyclopedia of Genes and Genomes; PI3K, phosphoinositide 3-kinase; Akt, RAC serine/threonine protein kinase; SMAD, mothers against decapentaplegic homolog.