Table I.

Target gene-associated pathways.

Pathway ID	Definition	Fisher P-value	Selection counts	Size	Enrichment-score	Genes
hsa04115	p53-signaling pathway	0.013	24	6890	1.86	APAF1//BAI1//BAX//BBC3//CASP8//CASP9//CCND3//CCNG2//CD82//CDK2//CDKN1A//CDKN2A//CHEK1//CYCS//DDB2//IGFBP3//RCHY1//RFWD2//RRM2B//SHISA5//TNFRSF10B//TP53//TSC2//ZMAT3
hsa04330	Notch-signaling pathway	0.001	21	6890	2.96	APH1A//CREBBP//CTBP2//DTX1//DTX3//DVL1//DVL2//DVL3//HDAC1//HDAC2//JAG2//KAT2A//LFNG//MFNG//NCOR2//NCSTN//NOTCH1//NOTCH2//NUMB//PSENEN//RFNG
hsa04621	NOD-like receptor-signaling pathway	0.005	22	6890	2.52	CARD6//CARD8//CARD9//CASP5//CASP8//CHUK//CXCL1//IKBKB//MAPK13//MAPK14//MAPK3//MEFV//NFKB1//NLRP1//NLRP3//NOD1//NOD2//PSTPIP1//PYCARD//RELA//SUGT1//TNF
hsa04668	TNF signaling pathway	<0.001	41	6890	3.34	AKT1//AKT2//BCL3//CASP10//CASP8//CEBPB//CHUK//CREB1//CREB3L2//CSF1//CXCL1//CXCL5//FADD//FOS//ICAM1//IKBKB//IL15//JUNB//MAP2K6//MAP2K7//MAP3K5//MAPK13//MAPK14// MAPK3//MMP14//MMP9//NFKB1// NOD2//PGAM5//PIK3CD//PIK3R5//PTGS2//RELA//RIPK1//RIPK3//RPS6KA5//TNF//TNFRSF1B//TRADD//TRAF1//TRAF3
hsa05222	Small cell lung cancer	0.008	30	6890	2.11	AKT1//AKT2//APAF1//BCL2//CASP9//CDK2//CDKN1B//CDKN2B//CHUK//COL4A3//CYCS//E2F2//FHIT//IKBKB//ITGA3//ITGA6//ITGAV//LAMA5//LAMB2//LAMC3//MYC//NFKB1//PIK3CD//PIK3R5//PTGS2//RELA//TP53//TRAF1//TRAF3//TRAF4
hsa05223	Non-small cell lung cancer	0.004	19	6890	1.399	AKT1//AKT2//ARAF//CASP9//CDKN2A//E2F2//FHIT//GRB2//HRAS//MAPK3//PDPK1//PIK3CD//PIK3R5//PLCG1//PRKCA//PRKCB//RASSF1//TGFA//TP53

CDKN2A is in the p53-signaling pathway. The Fisher P-values were 0.013 and 0.0039. CDKN2A was identified to be concentrated on the p53-signaling pathway according to the high-throughput sequencing results. TNF, tumor necrosis factor; CDKN2A, cyclin dependent kinase inhibitor 2A; NOD, nucleotide-binding oligomerization domain.