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Schematic showing NIPT using fNRBCs isolated by our nanostructure microchips. fNRBCs are captured from maternal peripheral blood by the biotin-doped Ppy nanoparticle microchip grafts with anti-CD147 targeting agent, and then retrieved from the substrate through electric stimulation. These isolated fNRBCs are used for chromosome analysis and whole exome sequencing to diagnose birth defects non-invasively.
