Figure 5.

CXCR4 overexpression increased the enrichment of hADSCs in the tumor hypoxic region of a mouse subcutaneous GBM xenograft model 5 days after tail-vein injection. (A) Schematic of experimental design. i.v., intravenous; SQ, subcutaneous. (B) Representative sections of the hypoxia targeting of CXCR4-overexpressing hADSCs (C) and untransfected hADSCs in subcutaneous tumor tissue. Blue, cell nuclei stained with DAPI; green, tumor hypoxic regions stained with pimonidazole; red, hADSCs labeled with PKH26. Scale bars = 100 μm. (C) Quantification of stem cells localized in hypoxia zone in tumor tissue. **p<0.01.