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Cellular uptake of cerium oxide nanoparticles (CNP) Squamous tumor cells of the skin were treated with 150 µM CNP or fluorescein isothiocyanate (FITC)-labeled CNP for 24 h. Data of studies with trans electron microscopy (left) indicate uptake of CNP (see arrows). Studies with FITC-CNP (green fluorescence) show distribution of CNP in the cytosol, while there appears no green fluorescence (or merged cyan fluorescence) of the nuclei (blue, 4′,6-Diamidin-2-phenylindol (DAPI)-staining).
