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. 2018 Feb 8;8(2):32. doi: 10.3390/brainsci8020032

Figure 1.

Figure 1

Schematic representation of convergent pathways of neuroprotection generalized for growth factors secreted by mesenchymal stem cells and synthetic antioxidants. Black arrows—physiological pathways; Red arrows—pathological pathways (wider arrow-hyperactivation); Red lighting—oxygen glucose deprivation (OGD); Red bars—inhibitory effect. ARE, antioxidant response element; gp130, glycoprotein 130; HSE, hypoxia response element; IL-6, interleukin 6; Mab, monoclonal antibody; P, Phosphorylated; ROS, radical oxygen species; TF, transcription factor; VEGF, vascular endothelial growth factor.